Postdoctoral Research Fellow in Genome Editing and Stem Cell Biology

Posted Date: 
Thursday, November 19, 2020
Department: 
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases
Position Description: 

All postdoctoral appointments are designated as security sensitive positions

UT Health San Antonio is an Equal Employment Opportunity / Affirmative Action Employer including protected veterans and persons with disabilities.

About the position

An open, fully funded postdoctoral position is available in the Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases at the University of Texas Health San Antonio (UTHSCSA) (https://biggsinstitute.org/).  We are seeking to recruit highly motivated individual expertise in cloning, cell culture, protein biochemistry (western blots, immunodetection), fluorescence-activated Cell Sorting (FACS), and confocal microscopy with interest in developing expertise in conducting research on brain disorders. Prior research experience or training in iPS/neural stem cell culture and CRISPR/Cas9 techniques are particularly encouraged to apply. The successful candidate will do genome editing based on our identified genomic targets on human iPS cells to evaluate their effects. The post-holder will be responsible for optimizing a protocol for the generation of edited cell lines. The future projects include differentiation the iPS cells to neurons and microglia. The position is open until filled.

Also, multiple PhD positions are available, research scholars with background of bioinformatics, computer science, biostatistics, molecular/cell biology are all encouraged to apply. Visiting scholars with related background are also welcome to join the lab.

About the lab

The functional genomics lab led by Dr. Liang Ma who has an appointment as an Assistant Professor at the Biggs Institute and Department of Pharmacology (see his profile: https://directory.uthscsa.edu/academics/profile/mal1).  He received his Ph.D. degree in Human Genetics at the University of Chinese Academy of Sciences. He performed his postdoc work in the School of Medicine of Johns Hopkins and Stanford. His research interest focuses on identifying causative genomic variations, genes, and splicing transcripts of human polygenic diseases using genome-wide association study (GWAS), whole-genome sequencing (WGS), RNA-seq, ChIP-seq, ATAC-seq, and DNA methylation. Using cutting-edge integrative omics approaches, he has identified a list of functional genetic variants and gene domains (e.g., SNX19, CYP2D6) that potentially increase the risk of schizophrenia. Another research interest of his lab is performing genome editing on neural stem cells of their identified genomic targets, followed by genome editing of human iPS cell lines, and differentiated them to functional neurons and glia for mechanism investigation. The results will help provide accurate molecular targets to guide the future development of precise and effective therapeutics.

About the institute

The Biggs Institute is a new flagship, free-standing institute within UTHSA with the mission of establishing an interdisciplinary, integrated program to provide comprehensive clinical care and undertake innovative and important research into the prevention and treatment of Alzheimer’s disease and other neurodegenerative conditions. It has strong institutional and community support and will benefit from existing resources within UTHSCSA. UTHSCSA is ranking #55 in Best Medical Schools: Research by US News (https://www.usnews.com/best-graduate-schools/top-medical-schools/the-university-of-texas-health-science-center-at-san-antonio-04114).

Position Requirements: 

We are seeking to recruit highly motivated individual expertise in cloning, cell culture, protein biochemistry (western blots, immunodetection), fluorescence-activated Cell Sorting (FACS), and confocal microscopy with interest in developing expertise in conducting research on brain disorders. Prior research experience or training in iPS/neural stem cell culture and CRISPR/Cas9 techniques are particularly encouraged to apply.

How to Apply: 

Applications should email their CV and contact information of three references to: Dr. Liang Ma, mal1@uthscsa.ed

Contact Name: 
Liang Ma, PhD
Contact Email: 
Deadline to Apply: 
Wednesday, March 31, 2021
Job Number: 
202

All postdoctoral appointments are designated as security sensitive positions. UT Health San Antonio is an Equal Employment Opportunity/Affirmative Action employer including protected veterans and persons with disabilities.