Ph.D

Uday  Pratap

Ph.D

OBGYN

Mentor:  Dr. Ratna K. Vadlamudi

Phone:  210-567-5019

Email:  pratap@uthscsa.edu

Education

2012 M. Tech SRM University, India
2017 Ph.D. SRM University, India

Honors

2019 Proteintech AACR Travel Grant
2012-2014 Best oral presentation award- World Noni Research Foundation, India
2011 CSIR NET- LS

Professional Memberships

2019-Present American Association for Cancer Research
2020 American Heart Association

Publications

  1. Li M, Viswanadhapalli S, Santhamma B, Pratap UP, Luo Y, Liu J, Altwegg KA, Tang W,Liu Z, Li X, Yan H, Sareddy GR, Xu Z,  Rao MK, Brenner A, Kaklamani VG,Tekmal RR, Ahmed G, Nickisch KJ, Nair HB, Raj GV, Vadlamudi RK. Targeted inhibition of LIFR enhances therapeutic efficacy of HDAC inhibitors in triple negative breast cancer. Journal of Clinical Investigation. (under revision).
  2. Sareddy, GR, Pratap UP, Venkata PP, Zhou Mei, Alejo A, Viswanadhapalli S, Tekmal, RR, Vadlamudi RK. Activation of estrogen receptor beta signalling reduces stemness of glioma stem cells. Stem Cells. (In press).
  3. Liu J, Liu Z, Li M, Tang W, Pratap UP, Luo Y, Altwegg KA, Li X, Zou Y, Zhu H, Sareddy, GR, Viswanadhapalli S, Vadlamudi RK. Interaction of Transcription factor AP-2 gamma with proto-oncogene PELP1 promote tumorigenesis by enhancing RET signaling. Molecular Oncology (In press).
  4. Zhou M, Venkata PP, Viswanadhapalli S, Palacios B, Alejo S, Chen Y, He Y, Pratap UP, Liu J, Zou Y, Lai Z, Suzuki T, Brenner AJ, Tekmal RR, Vadlamudi RK, Sareddy GR. 2020. KDM1A inhibition is effective in reducing stemness and treating triple negative breast cancer. Breast Cancer Res Treat. Oct 14. doi: 10.1007/s10549-020-05963-1.
  5. Wang J, Sareddy GR, Lu Y, Pratap UP, Tang F, Greene KM, Meyre PL, Tekmal RR, Vadlamudi RK, Brann DW. 2020. Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective Following Ischemic Brain Injury. J Neurosci. JN-RM-0888-20. doi: 10.1523/JNEUROSCI.0888-20.2020.
  6. Lu Y, Sareddy GR, Wang J, Zhang Q, Tang FL, Pratap UP, Tekmal RR, Vadlamudi RK, Brann DW. 2020. Neuron-Derived Estrogen Is Critical for Astrocyte Activation and Neuroprotection of the Ischemic Brain. J Neurosci. 40(38):7355-7374. doi: 10.1523/JNEUROSCI.0115-20.2020. Epub 2020 Aug 19. PMID: 32817249; PMCID: PMC7534920
  7. Pratap UP, Hima L, Kannan T, Thyagarajan C, Priyanka HP, Vasantharekha R, Pushparani A, ThyagaRajan S. 2020. Sex-based differences in the cytokine production and intracellular signaling pathways in patients with rheumatoid arthritis. Arch Rheumatol. doi:10.46497/ArchRheumatol.2020.7481.
  8. Hima L, Patel MN, Kannan T, Gour S, Pratap UP, Priyanka HP, Vasantharekha R, ThyagaRajan S. 2020. Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways. J Neuroimmunol. 345:577290. doi: 10.1016/j.jneuroim.2020.577290.
  9. Viswanadhapalli S, Ma S, Sareddy GR,  Lee TK;  Li M; Gilbreath C, Liu X,  Luo Y;  Pratap UP, Zhou M, Blatt EB, Kassees K, Arteaga C, Alluri P, Rao M,  Weintraub ST, Tekmal RR,  Ahn JM, Raj GV, Vadlamudi RV. 2019. Estrogen receptor coregulator binding modulator (ERX-11) enhances the activity of CDK4/6 inhibitors against estrogen receptor-positive breast cancers. Breast Cancer Res. 26, 21-150. doi: 10.1186/s13058-019-1227-8.
  10. Sareddy GR, Pratap UP, Viswanadhapalli S, Venkata PP, Nair BC, Krishnan SR, Zheng S, Gilbert AR, Brenner AJ, Brann DW, Vadlamudi RK. 2019. PELP1 promotes glioblastoma progression by enhancing Wnt/β-catenin signaling. Neuro-Oncology Advances, Volume 1, Issue 1, May-December 2019, vdz042, doi.org/10.1093/noajnl/vdz042.
  11. Luo Y, Li M, Pratap UP, Viswanadhapalli S, Liu J, Venkata PP, Altwegg KA, Palacios BE, Li , Chen Y, Rao MK, Brenner AJ, Sareddy GR, Vadlamudi RK. 2020. PELP1 signaling contributes to medulloblastoma progression by regulating NF-κb pathway. MolCarcinog. 59, 281-292. doi: 10.1002/mc.23152.
  12. Hima L, Pratap UP, Karrunanithi S, Ravichandran KA, Vasantharekha R, ThyagaRajan S. 2019. Virgin coconut oil supplementation in diet modulates immunity mediated through survival signaling pathways in rats. J Complement Integr Med. pii: /j/jcim.ahead-of-print/jcim-2019-0114/jcim-2019-0114.xml. doi: 10.1515/jcim-2019-0114.
  13. Karrunanithi S, Ravichandran KA, Hima L, Pratap UP, Vasantharekha R, ThyagaRajan S. 2019. Virgin coconut oil enhances neuroprotective and anti-inflammatory factors in the thymus and mesenteric lymph nodes of rats. Clinical and Experimental Neuroimmunology, 11, 65-72. doi.org/10.1111/cen3.12540.
  14. ThyagaRajan S, Hima L, Pratap UP, Priyanka HP, Vasantharekha R. 2018. Estrogen-induced neuroimmunomodulation as facilitator of and barrier to reproductive aging in brain and lymphoid organs. J Chem Neuroanat. S0891-0618(17)30189-8. doi: 10.1016/j.jchemneu.2018.02.008.
  15. Viswanadhapalli S, Luo Y, Sareddy GR, Santhamma B, Zhou M, Li M, Ma S, Sonavane R, Pratap UP, Altwegg KA, Li X, Chang A, Chávez-Riveros A, Dileep KV, Zhang KYJ, Pan X, Murali R, Bajda M, Raj GV, Brenner AJ, Manthati V, Rao MK, Tekmal RR, Nair HB, NickischKJ, Vadlamudi RK. 2019. EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer. Mol Cancer Ther. doi: 10.1158/1535-7163.MCT-18-1258.
  16. Pratap UP, Priyanka HP, Ramanathan KR, Raman V, Hima L, Thyagarajan S. 2018. Noni (Morindacitrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes of old F344 rats. J Integr Med.16, 199-207. doi: 10.1016/j.joim.2018.04.002.
  17. Aravind RK, Sunil K, Hima L, Pratap UP, Priyanka HP, ThyagaRajan S. 2017. Estrogen differentially regulates the expression of tyrosine hydroxylase and nerve growth factor through free radical generation in thymus and mesenteric lymph nodes of middle-aged ovariectomized female Sprague-Dawley rats. Clinical and Experimental Neuroimmunology. 8, 341-350. doi: 10.1111/cen3.12415.
  18. Pratap UP, Hima L, Priyanka HP, ThyagaRajan S. 2017. Noni (Morinda citrifolia L.) fruit juice reverses age-related decline in neural-immune interactions in the spleens of old F344 rats. J Ethnopharmacol. 198, 363-371. doi: 10.1016/j.jep.2017.01.034.
  19. Pratap UP, Patil A, Sharma HR, Hima L, Chockalingam R, Hariharan MM, Shitoot S, Priyanka HP, ThyagaRajan S. 2016. Estrogen-induced neuroprotective and anti-inflammatory effects are dependent on the brain areas of middle-aged female rats. Brain Res. Bull. 124, 238-253. doi: 10.1016/j.brainresbull.2016.05.015.
  20. Pratap UP, Anand K, Yasmine F, Hima L, Priyanka HP, ThyagaRajan S. 2016. Phytochemicals in Morindacitrifolia fruit selectively modulate age-associated immunity and antioxidant enzyme activities through ERK pathway in splenic lymphocytes of male F344 rats. J Receptor Signal Transduct Res. 36, 139-151. doi: 10.3109/10799893.2015.1061001.
  21. Pratap UP, Sharma HR, Mohanty A, Kale P, Gopinath S., Hima L, Priyanka HP, ThyagaRajan S. 2015. Estrogen upregulates inflammatory signals through NF-κB, IFN-γ and nitric oxide via Akt/mTOR pathway in the lymph node lymphocytes of middle-aged female rats. IntImmunopharmacol. 29, 591-598. doi: 10.1016/j.intimp.2015.09.024
  22. Kale P, Mohanty A, Mishra M, Pratap UP, Priyanka HP, ThyagaRajan S. 2014. Estrogen modulates neural-immune interactions through intracellular signaling pathways and antioxidant enzyme activity in the spleen of middle-aged ovariectomized female rats. J Neuroimmunol. 267, 7-15. doi: 10.1016/j.jneuroim.2013.11.003.
  23. Priyanka HP, Singh RV, Pratap UP, ThyagaRajan S. 2014. Estrogen modulates b2-adrenoceptor-induced cell-mediated and inflammatory immune responses through ER-α involving distinct intracellular signaling pathways, antioxidant enzymes, and nitric oxide. Cell Immunol. 292, 1-8. doi: 10.1016/j.cellimm.2014.08.001.