Postdoctoral Fellow

Charles  Fermaintt

Postdoctoral Fellow

Pharmacology

Mentor:  April L. Risinger

Phone:  2104508950

Email:  Fermaintt@uthscsa.edu

Education

2011 B.S. Chemistry University of Puerto Rico at Humacao
2018 Ph.D. Biological Chemistry University of Texas Southwestern Medical Center

Research

As a postdoctoral fellow in Dr. April L. Risinger's laboratory, I am focusing on identifying and characterizing drugs derived from natural sources like plants and fungi that could be used to develop more effective cancer-immunotherapies against breast cancer in particular triple-negative breast cancer (TNBC). I am also examining the influence of clinically used chemotherapy agents like microtubule targeting agents (MTA) on the innate immune system.

Honors

2017 Outstanding Poster Presentation Award (UT-Soutwestern Biological Chemistry Symposium)
2017, 2016, 2015 Travel Award (Society for Glycobiology)
2013-2016 National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP)
2011-2012 Postbaccalaureate Research Education Program (PREP) (NIH R25), Postbacc
2009-2011 Minority Access to Research Careers (MARC) (NIH T34), Undergraduate researcher
2007-2011 AMGEN Foundation Scholarship
2018-present UT-Health San Antonio SABER (IRACDA) Scholar (NIH K12), Postdoctoral Fellow

Professional Memberships

2019-Present American Society of Pharmacognosy (ASP)
2018-Present UT-Health San Antonio Postdoctoral Association, Event Manager (2019)
2015-2018 Society of Glycobiology
2013-2018 UT-Southwestern Graduate Student Organization, Vice-President (2016)
2008-2011 American Chemical Society (ACS)

Publications

Fermaintt C.S., Sano K., Liu Z., Ishii N., Seino J., Dobbs N., Suzuki T., Fu Y., Lehrman M.A., Matsuo I., and Yan N. A bioactive mammalian disaccharide activates a STING-TBK1-dependent immune response associated with chronic autoimmune disease. Nature Communications, 2019 PMID: 31147550

 

Lu H., Fermaintt C.S., Yan N. and Lehrman M.A. Mammalian oligosaccharyltransferases segregate LLO donor hydrolysis from N-glycosylation at the translocon. PNAS, 2018 PMID: 30181269

 

Sakai T., Miyazaki T., Shin D., Kim Y., Qi C., Fariss R., Munasinghe J., Wang H., Kovalchuk A.L., Kothari P.H., Fermaintt C.S., Atkinson J.P., Perrino F.W., Yan N., Morse III H.C. DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice. Journal of Autoimmunity, 2017 PMID: 28325644

                

Kucej M.*, Fermaintt C.S.*, Yang K., Irizarry-Caro R. and Yan N. Mitotic phosphorylation of TREX1 C-terminus disrupts TREX1 regulation of the oligosaccharyltransferase complex. Cell Reports, 2017 PMID: 28297665  *Co-first author

 

Hasan M.*, Fermaintt C.S.*, Gao N., Sakai T., Miyazaki T., Jiang S., Li Q., Atkinson J.P., Morse III H.C., Lehrman M.A. and Yan N. A novel function of TREX1 associated with the C-terminus connects oligosaccharyltransferase dysregulation to immune disorders. Immunity, 2015 PMID: 26320659 *Co-first author

 

Pham N.D., Fermaintt C.S., Rodriguez A.C., McCombs J.E., Nischan N and Kohler J.J. Cellular metabolism of unnatural sialic acid precursors. Glycoconjugate Journal, 2015 PMID: 25957566