Postdoctoral Fellow

Binu  Kandathilparambil Sasi

Postdoctoral Fellow

Medicine

Mentor:  Ricardo CT Aguiar

Email:  sasi@uthscsa.edu

ORCID iD:  0000-0002-3325-9874

Education

2014 PhD Indian Institute of Technology Madras

Honors

2019 Abstract Achievement Award , American Society of Hematology

Professional Memberships

2019 Associate Member, Mays Cancer Center

Publications

  1. Vervloessem T, Sasi BK*, Xerxa E, Karamanou S, Kale J, La Rovere RM, Chakraborty S, Sneyers F, Vogler M, Economou A, Laurenti L, Andrews DW, Efremov DG, Bultynck G. (2020) BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models. Cell Death Dis. 2020 Sep 17;11(9):769. doi: 10.1038/s41419-020-02944-6. * (equal first author contribution).
  2. Sasi B, Ethiraj P, Myers J, Lin AP, Jiang S, Qiu Z, Aguiar RCT. (2020) Regulation of PD-L1 expression is a novel facet of cyclic-AMP-mediated immunosuppression. Leukemia. https://doi.org/10.1038/s41375-020-01105-0.
  3. Qiu Z, Lin AP, Jiang S, Elkashef SM, Myers J, Srikantan S, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, Zheng S, Madesh M, Shiio Y, Dahia PLM, Aguiar RCT. (2020) MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome. Cell Chem Biol. 2020 May 21;27(5):538-550.e7.
  4. Sasi BK, Martines C, Xerxa E, Porro F, Kalkan H, Fazio R, Turkalj S, Bojnik E, Pyrzynska B, Stachura J, Zerrouqi A, Bobrowicz M, Winiarska M, Priebe V, Bertoni F, Mansouri L, Rosenquist R, Efremov DG. (2019) Inhibition of SYK or BTK augments venetoclax sensitivity in SHP1-negative/BCL-2-positive diffuse large B-cell lymphoma. Leukemia 2019 Mar 1 doi: 10.1038/s41375-019-0442-8.
  5. Gupta V, Kapopara PR, Khan AA, Arige V, Subramanian L, Sonawane PJ, Sasi BK, Mahapatra NR. (2017) Functional promoter polymorphisms direct the expression of cystathionine gamma-lyase gene in mouse models of essential hypertension. J Mol Cell Cardiol.102:61-73.
  6. Bojarczuk K*, Sasi BK*, Gobessi S, Innocenti I, Pozzato G, Laurenti L, Efremov DG. (2016) BCR signaling inhibitors differ in their ability to overcome Mcl-1-mediated resistance of CLL B cells to ABT-199. Blood. 127(25):3192-201. * (equal first author contribution).
  7. Gupta V, Khan AA, Sasi BK, Mahapatra NR. (2015) Molecular mechanism of monoamine oxidase A gene regulation under inflammation and ischemia-like conditions: key roles of the transcription factors GATA2, Sp1 and TBP (2015) J Neurochem, 134(1):21-38.
  8. Sonawane PJ, Gupta V, Sasi BK, Kalyani A, Natarajan B, Khan AA, Sahu BS, Mahapatra NR. (2014) Transcriptional regulation of the novel monoamine oxidase renalase: Crucial roles of transcription factors Sp1, STAT3, and ZBP89. Biochemistry, 53(44):6878-92.
  9. Sasi BK, Sonawane PJ, Gupta V, Sahu BS, Mahapatra NR. (2013) Coordinated Transcriptional Regulation of Hspa1a Gene by Multiple Transcription Factors: Crucial Roles for HSF-1, NFY, NF-κB and CREB. Journal of Molecular Biology, 426(1):116-35.
  10. Sahu BS, Obbineni JM, Sahu G, Allu PK, Subramanian L, Sonawane PJ, Singh PK, Sasi BK, Senapati S, Maji SK, Bera AK, Gomathi BS, Mullasari AS, Mahapatra NR. (2012) Functional Genetic Variants of the Catecholamine-Release-Inhibitory Peptide Catestatin in an Indian Population: Allele-Specific Effects on Metabolic Traits. Journal of Biological Chemistry, 287(52):43840-52.
  11. Sahu BS, Obbineni JM, Sahu G, Singh PK, Sonawane PJ, Sasi BK, Allu PK, Maji SK, Bera AK, Senapati S, Mahapatra NR. (2012) Molecular mechanism of interactions of the physiological anti-hypertensive peptide catestatin with the neuronal nicotinic acetylcholine receptor. Journal of Cell Science, 125:2323-37.
  12. Sonawane PJ*, Sahu BS*, Sasi BK*, Geedi P, Lenka G, Mahapatra NR.  (2011) Functional promoter polymorphisms govern differential expression of HMG-CoA Reductase gene in mouse models of essential hypertension. PLoS one, Volume 6, Issue 1: e16661.
  13. Abdul Khaliq R, Sonawane PJ, Sasi BK, Sahu BS, Pradeep T, Das SK, Mahapatra NR. Enhancement in the efficiency of polymerase chain reaction by TiO2 nanoparticles: crucial role of enhanced thermal conductivity. Nanotechnology, 25; 21(25): 255704.