Postdoctoral Fellow

Ajinkya  Kawale

Postdoctoral Fellow

Biochemistry and Structural Biology

Mentor:  Dr. Patrick Sung

Email:  kawale@uthscsa.edu

Education

2015 MS Molecular Biology and Genetics Virginia Commonwealth University
2018 PhD Pharmacology and Toxicology Virginia Commonwealth University

Research

Genome instability

DNA repair pathway choice

DNA End resection 

 

 

Honors

2019 CPRIT Postdoctoral Research Training Award
2018 Jan Chlebowski Award for Outstanding Achievement in Doctoral Studies
2018 Lauren A. Woods Award for Research Excellence in Doctoral Studies
2018 Charles C. Clayton Award
2017 Award for Excellence in Cancer Research
2017 Graduate Dissertation Assistantship Award
2017 Phi Kappa Phi Scholarly Achievement Award

Professional Memberships

2019 AAAS
2015 Phi Kappa Phi Honor Society
2015 American Society for Pharmacology and Experimental Therapeutics

Publications

Jiang H, Xue X, Panda S, Kawale AS, Hooy RM, Liang F, Sohn J, Sung P & Gekara NO. (2019). Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death. EMBO J. 2019 Sep 23: e102718. doi: 10.15252/embj.2019102718.

Saleh T, Tyutyunyk-Massey L, Murray GF, Alotaibi MR, Kawale AS, Elsayed Z, Henderson SC, Yakovlev V, Elmore LW, Toor A, Harada H, Reed J, Landry J & Gewirtz DA. (2018). Tumor cell escape from therapy-induced senescence. Biochem Pharmacol. doi: 10.1016/j.bcp.2018.12.013.

Chalasani SL, Kawale AS, Akopiants K., Fanta, M., Weinfeld, M. and Povirk LF. (2018). Persistent 3′-phosphate termini and increased cytotoxicity of radiomimetic DNA DSBs in Polynucleotide Kinase/ Phosphatase-deficient cells despite presence of an alternative 3′-phosphatase. DNA Repair. Aug; 68:12-24. doi: 10.1016/j.dnarep.2018.05.002.

Kawale AS, Akopiants K, Valerie K, Ruis BA, Hendrickson EA, Huang SY, Pommier Y and Povirk LF. (2018). TDP1 suppresses misjoining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining. Nucleic Acids Res. 46(17):8926-8939. doi: 10.1093/nar/gky694.

Kawale AS and Povirk LF. (2017). Tyrosyl-DNA Phosphodiesterases: rescuing the genome from the risks of relaxation. Nucleic Acids Res. 46(2):520-537. doi: 10.1093/nar/gkx1219.