The Hopp Lab, part of the Biggs Institute for Alzheimer’s and Neurodegenerative Diseases and the Department of Pharmacology at UT Health Science Center San Antonio, is seeking postdoctoral fellows to engage in ongoing studies on the role of microglia in Alzheimer’s disease and other brain disorders. We are particularly interested in understanding the dual role of microglia during neurodegenerative diseases in the propagation of neurotoxicity and restoration of homeostasis. Our lab uses a multi-level approach to understand microglia biology during disease, ranging from cell culture to transgenic animal models to human tissue samples. We have a friendly and open lab environment with several ongoing collaborations across different research modalities and departments. The Hopp Lab is currently focused on two main research areas. One broad area interrogates the role of calcium signaling in microglia-neuron interactions during Alzheimer’s disease, Parkinson’s disease, and other disorders. The second broad area focuses on microglia internalization of misfolded proteins during Alzheimer’s and Parkinson’s disease, particularly tau but also amyloid β and synuclein. Applicants are expected to independently design experiments that contribute to the overall research focus of the lab. The initial appointment is for one year and is renewable for reappointment. Postdoctoral fellows are expected to apply for independent research funding within the first year, but reappointment is not strictly dependent on independent funding.
This position requires a PhD in neuroscience, biology, pharmacology, or a related field and less than 2 years of previous postdoctoral job experience. Strong written and oral communication skills are required.
Willingness to work with mouse models is required. Experience with mouse work is preferred, but not mandatory. Experience with neurodegenerative disease models and mouse behavior is also beneficial.
Some previous hands-on experience with lab techniques such as immunohistochemistry, western blotting, cell culture, molecular biology, and/or qPCR is desired.
Applicants with prior experience with live in vitro cell imaging, calcium imaging, RNA sequencing, flow cytometry, neuron-glia interactions, or in vivo multiphoton imaging will be given priority consideration.
Email the following items to Dr. Sarah Hopp at firstname.lastname@example.org:
- A cover letter describing previous relevant research experience, what specific Hopp Lab project you are interested in, and your career goals.
- CV including a list of publications
- A writing sample (e.g. example publication written by the applicant)
- Contact information for three references