Postdoctoral Research Fellow in Pathophysiology

Posted Date: 
Wednesday, March 15, 2017
Cell and Integrative Physiology
Position Description: 

This posting is to fill open positions in our T32 post-doctoral training grant, “The Pathophysiology of Occlusive Vascular Disease” in the laboratory of Mark S. Shapiro, Ph.D. in the Department of Physiology. We study the physiology, regulation and functional role of a variety of ion channels in neurons and other excitable cells, using a range of cutting-edge molecular, cellular and integrative approaches. This T32 training grant, that Dr. Shapiro participates in, has produced a number of NRSA F32-funded investigators who have gone on to successful faculty positions. The positions should be filled by the end of August 2017, or October 1, 2017 at the latest.
In my group, previous and current post-docs supported by this T32 training grant have studied, or are studying, the roles of KCNQ potassium ion channel activity in neurons of the brain as a neuroprotective mechanism against brain damage induced by stroke, traumatic brain injury (TBI), and epileptic seizures leading to epileptogenesis. The project on TBI and epileptogenesis is also supported by a grant from the DoD CDMRP program. We use whole-animal in vivo stroke, TBI and SCI models in a variety of wild-type or genetically-altered mice, and study the brain using brain-slice electrophysiology, immunochemistry, in vivo confocal imaging and in vivo behavioral assays. We are very physiological and quantitative in approach, yet with strong translational relevance and potential. The candidate can thus learn patch-clamp methods and innovative imaging (deep brain to single-cell) techniques, in conjunction with molecular and live-animal behavioral approaches. T32-supported candidates benefit from a number of grant-writing and career-building workshops, which have proven extremely valuable as post-doctoral fellows progress to independence. We also employ super-resolution microscopy, molecular biology, biochemistry patch clamp of tissue-culture cells and dissociated neurons to discover that intracellular 2nd-messengers the couple receptors to alterations in ion channel activity and cellular function.

UTHSCSA is a leading academic research university, and the Department of Cell and Integrative Physiology in the School of Medicine contains a vibrant mix of neuroscientists, cellular/molecular physiologists and integrative systems scientists who interact often and well. The Shapiro lab at UTHSCSA which contains an interdepartmental and collaborative group of funded and productive neuroscientists and cardiovascular researchers. San Antonio is a vibrant and multi-cultural city with many attractions, and offers a very affordable cost of living for a post-doctoral fellow supported by this T32 training grant.

We seek highly-motivated and hard-working candidates with strong scholarly outlook, and a keen desire to perform cutting-edge biomedical research. A background in cardiovascular physiology, neurophysiology, mammalian models and ion channel physiology/pharmacology is preferred, but all candidates will be considered. Since this is a T32-supported or DoD-supported position, US citizenship or permanent residency status (green card) is preferred, but citizens of all countries will be considered based on experience and qualifications. All postdoctoral appointments are designated as security sensitive positions.

Position Requirements: 

Ph.D. or M.D. and three letters of recommendation

How to Apply: 

To apply, please email Dr. Shapiro at

Contact Name: 
Mark S. Shapiro
Contact Email: 
Deadline to Apply: 
Saturday, July 15, 2017
Job Number: 

All postdoctoral appointments are designated as security sensitive positions. UT Health San Antonio is an Equal Employment Opportunity/Affirmative Action employer including protected veterans and persons with disabilities.