The Combat Casualty Care Directorate at the Naval Medical Research Unit San Antonio (NAMRU-SA) seeks a highly motivated scientist as a postdoctoral fellow to evaluate the in vitro and in vivo regenerative ability of adult stromal cells derived from different tissue types to grow and differentiate on a novel scaffold and regenerate bone in small and/or large animal models. The overall goal of the project is to develop a novel stromal-cell based therapeutic that can accelerate the regenerative process of critical size bone defects inflicted by combat-related wounds. The participant will have the opportunity to collaborate with accomplished scientists within NAMRU-SA and with external organizations to accelerate the development of novel therapeutics for combat casualty care. This is a unique opportunity for a talented scientist with experience in stromal cell and molecular biology to work in a dynamic and innovative environment to address some of the most pressing clinical needs in the care of U.S. military personnel.
Under the direction of the principal investigator, the participant will:
- Assist in the formulation of research hypotheses, design and conduct experiments, collect, analyze and interpret data.
- Perform in vitro and in vivo studies to evaluate the safety and efficacy of stromal cell-derived therapeutics in combat-related wound models.
- Perform in vitro studies to evaluate and compare the osteogenic differentiation potential of adult stromal cells derived from various tissues using cell and molecular techniques.
- Evaluate the ability of stromal cells derived from different tissue types to grow and differentiate on novel biomaterials in 3D culture.
- Perform small animal critical size calvarial bone defect surgeries to implant the therapeutics into and assess in vivo bone regeneration.
- Assist collaborators with microCT scanning, analysis and histology to assess the degree of regenerated bone.
- Assist collaborators with mechanical testing of the biomaterials and regenerated bone obtained from the in vivo
- Prepare and present findings internally and externally through briefings, seminars, conferences, and publication in high impact journals.
- Prepare research proposals, IACUC protocols, technical reports, presentation materials, manuscripts for peer review, and patent applications.
- Work cross-functionally in a multidisciplinary environment.
BENEFITS OF PARTICIPATING IN THE ORISE PROGRAM
Selected Fellows/Researchers will have the opportunity to perform research on topics of interest to the U.S. Government and to interact with leading scientists performing research and/or advising at the sponsor. The extensive partnering relationships with universities and other government agencies will expose participants to a broad research community. Program participants will have the opportunity to meet government decision-makers and learn directly from them about the role of scientific research in addressing complex, real-world (i.e., operational) needs. Furthermore, fellows have the opportunity to learn how research products transition from the proof-of-concept stage to integrated production systems. Other benefits may include the following:
• Stipend Payments
• Health Insurance
• Inbound Relocation/Dislocation
• Training & Travel
Applicants should have recently completed a degree within five years of the desired starting date in or related discipline, or will be able to complete of all requirements for the degree within six months of the starting date. Other applicants will be considered on a case-by-case basis. The program is open to all qualified U.S. citizens without regard to race, sex, religion, color, age, physical or mental disability, national origin, or status as a Vietnam era or disabled veteran.
· PhD in biology, cell and molecular biology, molecular biology or related discipline.
· Extensive experience working with, and culturing human cells under aseptic conditions
· Experienced with various cell and molecular techniques such as cell proliferation assays, live/dead staining, nucleic acid extraction, qPCR, ELISA and western blots.
Applications are accepted and reviewed on an ongoing basis. Selections are made as openings occur throughout the year. A complete application includes: profile, two references, and transcripts for all degrees earned and/or currently attending. Follow link to apply - http://tinyurl.com/jsb7pje
The participants will be selected based on academic records, recommendations, applied research interests and compatibility of background with applied research programs and projects at the host Installation. The initial appointment is typically for one year and may be renewed for up to four additional years based upon recommendation of the host installation and subject to availability of funds. The participant will receive a monthly stipend which is determined based upon level of education, training, and experience. Inbound travel and moving expenses are reimbursed according to established policies. Travel and other costs will also be reimbursed for training related to the project and approved by ORAU and the host installation. The participant must show proof of health and medical insurance. Health plans are available through the ORAU for Postgraduate Internship participants.