Postdoctoral fellowship position is available immediately in the Department of Pathology & Laboratory Medicine, Lozano Long School of Medicine, University of Texas Health Science Center San Antonio to investigate molecular mechanisms that regulate cardiac hypertrophy and remodeling in response to stresses. The main objective is to determine how canonical Wnt/ beta-catenin signaling interacts with TCF7L2 isoforms regulate cardiac gene expression and structural remodeling. Gene expression and epigenetic modifications will be investigated and interpreted in the context of TCF7L2 isoform recruitment. Spatial genomics and NGS will be utilized to investigate regional differences in gene expression and Wnt signaling. S/he will perform gene expression profiling, confocal microscopy and image analysis, chromatin immunoprecipitation, and cardiac function measurements. Data generated in genetic mouse models will be interpreted in the context of different types of failing human hearts with distinct pathologic findings. The candidate will be encouraged to develop independent research projects and seek extramural funding.
Applicants should have a Ph.D., M.D. or equivalent doctoral degree and research expertise in molecular cardiology and cardiac physiology. Candidates with a strong background in genomic analysis tools and methods, differential gene expression, WNT signaling, RNA isoform switching, and gene targeting are encouraged to apply. Preference will be given to individuals with training and/or expertise in signal transduction and molecular biology.
Please send a curriculum vitae, a statement of research interest and contact information for three Professional references to: Dr. Faqian Li (lif2@uthscsa.edu)