Alberto Castro Molina
Postdoctoral Research Fellow
I am a physician and postdoctoral research fellow at UT Health San Antonio, where my work focuses on vascular health, brain aging, and cognitive decline within the San Antonio Heart Study (SAHMS). My research interests lie at the intersection of clinical medicine and translational neuroscience, with an emphasis on understanding systemic contributors to neurodegeneration.
A central theme of my work is bioenergetics, particularly how metabolic pathways influence vascular function and brain health across the aging process. I am especially interested in the role of creatine metabolism, inflammation, and vascular dysfunction as modifiable factors in cognitive impairment. Through this lens, I aim to identify mechanistic links that can be translated into clinically meaningful interventions.
In parallel, I am interested in non-opioid strategies for pain management, exploring metabolic and vascular modulation as potential therapeutic avenues. My broader goal is to develop accessible, mechanism-driven approaches that improve outcomes in both neurological and chronic systemic diseases.
Ultimately, I aspire to build an academic career that integrates clinical practice with translational research, bridging bench-to-bedside discovery to improve patient care. I am committed to advancing innovative, evidence-based strategies that address the growing burden of cognitive decline and chronic disease in aging populations.
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Professional Background
Education
- 2018 - Doctor Of Medicine - Faculty of Medicine of the Valle de México University
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Research
My research interests lie at the intersection of clinical medicine and translational neuroscience, with an emphasis on understanding systemic contributors to neurodegeneration. I am particularly focused on the role of vascular health and systemic bioenergetics in brain aging and cognitive decline, with ongoing work within the San Antonio Heart Study (SAHMS). A key area of interest is the relationship between aerobic capacity (VO₂max), sarcopenia, and cognitive performance, exploring how peripheral physical decline may reflect or contribute to central nervous system vulnerability. I am also interested in creatine metabolism as a potential modulator of cellular energetics in both skeletal muscle and the brain, and how bioenergetic resilience may influence aging trajectories. Through this integrative framework, I aim to identify mechanistic links between muscle health, vascular function, and neurodegeneration that can be translated into preventive and therapeutic strategies.
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Publications
Quantitative differences in the white matter connections of DBS contacts and the
clinical outcome in Parkinson's disease
Victoria E. Ragland, Marucela J. Uscamayta Ayvar, Juan Toranzo, Javier Arnedo
Alberto Castro Molina, Gabriel A. de Erausquin
DOS : https://doi.org/10.1016/j.brs.2018.12.140