Office of Postdoctoral Affairs

Thiago Macedo e Cordeiro

Postdoctoral Research Fellow

Dr. Thiago Macedo e Cordeiro is a physician-scientist and postdoctoral research fellow at UT Health San Antonio whose career has been defined by a commitment to bridging disciplines in pursuit of solutions for complex neuropsychiatric and neurodegenerative disorders. Trained as a medical doctor in Brazil, Dr. Cordeiro went on to earn a Master of Science in Neuroscience before starting his postdoctoral fellowships in neuropsychiatry at UT Health San Antonio.

Dr. Cordeiro’s research spans medicine, neuroscience, immunology, computer science, and neuroimaging, with a focus on the biological mechanisms underlying psychiatric and cognitive symptoms. His early studies examined the role of systemic inflammation in brain disorders, and his more recent work combines structural imaging, biomarker analysis, and non-invasive neuromodulation approaches such as transcranial direct current stimulation (tDCS). He also applies bioinformatics and machine learning methods to better characterize disease mechanisms and to explore new therapeutic strategies for neurodegenerative conditions including Alzheimer’s disease, Huntington’s disease, and Parkinson’s disease.

In addition to his research, Dr. Cordeiro is actively involved in mentoring and teaching, fostering an environment of collaboration between clinical investigators, computational scientists, and trainees. His work has been recognized through competitive awards from the Alzheimer’s Association and the Huntington’s Disease Society of America, where he serves as Principal Investigator on studies exploring home-based neuromodulation for cognitive and behavioral symptoms.

Through his cross-disciplinary expertise and translational vision, Dr. Cordeiro is advancing research that deepens understanding of brain–immune interactions and behavioral symptoms and also translates directly into accessible, patient-centered interventions. His ultimate goal is to catalyze innovative approaches that unite complementary fields of knowledge to improve the lives of individuals and families affected by neurodegenerative and psychiatric disease.

  • Publications
    1. Cordeiro TME, Mwangi B, Carreira EX, Prado ACA, Tavares F, Cardoso F, Jaeger A, de Souza LC, Furr Stimming E, Teixeira AL, Rocha NP. Investigating the structural neuroimaging signature of apathy in Parkinson's disease. Behav Brain Res. 2025;493:115664. doi:10.1016/j.bbr.2025.115664.
    2. Machado CA, Oliveira BDS, Dias TL, Barros JLVM, Ferreira GMF, Cordeiro TM, Feracin V, Alexandre CH, Abreu LKS, Silva WND, Carvalho BC, Fernandes HB, Vieira ELM, Castro PR, Ferreira RN, Kangussu LM, Franco GR, Guatimosim C, Barcelos LDS, Simoes e Silva AC, Toscano ECB, Rachid MA, Teixeira AL, Miranda AS. Weight-drop model as a valuable tool to study potential neurobiological processes underlying behavioral and cognitive changes secondary to mild traumatic brain injury. J Neuroimmunol. 2023;385:578242. doi:10.1016/j.jneuroim.2023.578242.
    3. Teixeira AL, Martins LB, Cordeiro TME, Jose L, Suchting R, Holmes HM, Acierno R, Ahn H. Home-based tDCS for apathy in Alzheimer's disease: a protocol for a randomized double-blinded controlled pilot study. Pilot Feasibility Stud. 2023;9(1):74. PMID:37147739; PMCID:PMC10161588.
    4. Jose L, Martins LB, Cordeiro TM, Lee K, Diaz AP, Ahn H, Teixeira AL. Non-invasive neuromodulation methods to alleviate symptoms of Huntington's disease: a systematic review of the literature. J Clin Med. 2023;12(5):2002. doi:10.3390/jcm12052002.
    5. Machado CA, Silva ACSE, de Miranda AS, Cordeiro TME, Ferreira RN, de Souza LC, Teixeira AL. Immune-based therapies for traumatic brain injury: insights from pre-clinical studies. Curr Med Chem. 2020;27(32):5374-5402. doi:10.2174/0929867326666190719123028.
    6. Ribeiro VT, Cordeiro TM, Perez LG, Caramelli P, Teixeira AL, Souza LC, Silva ACS. Circulating angiotensin-(1-7) is reduced in Alzheimer's disease patients and correlates with white matter abnormalities: results from a pilot study. Front Neurosci. 2021;15:369. doi:10.3389/fnins.2021.636161.
    7. Mohite S, Salem H, Cordeiro T, Tannous J, Mwangi B, Selvaraj S, Soares JC, Sanches M, Teixeira AL. Correlations between peripheral levels of inflammatory mediators and frontolimbic structures in bipolar disorder: an exploratory analysis. CNS Spectr. 2021;14:1-6. doi:10.1017/S109285292100003X.
    8. Cordeiro TM, Zhang X, Graubics K, Colwell R, Teixeira AL. Microbiome and schizophrenia: current evidence and future challenges. Curr Behav Neurosci Rep. 2020;7:51-61. doi:10.1007/s40473-020-00202-9.
    9. Mohite S, Cordeiro TM, Tannous J, Mwangi B, Selvaraj S, Soares JC, Sanches M, Teixeira AL. Eotaxin-1/CCL11 correlates with left superior temporal gyrus in bipolar disorder: a preliminary report suggesting accelerated brain aging. J Affect Disord. 2020;273:592-596. doi:10.1016/j.jad.2020.05.062.
    10. Lanza K, Perez LG, Costa LB, Cordeiro TM, Palmeira VA, Ribeiro VT, Silva ACSE. COVID-19: the renin–angiotensin system imbalance hypothesis. Clin Sci. 2020;134:1259-1264. doi:10.1042/CS20200492.
    11. Hunt C, Cordeiro TM, Suchting R, de Dios C, Cuellar Leal VA, Soares JC, Dantzer R, Teixeira AL, Selvaraj S. Effect of immune activation on the kynurenine pathway and depression symptoms: a systematic review and meta-analysis. Neurosci Biobehav Rev. 2020;118:514-523. doi:10.1016/j.neubiorev.2020.08.010.
    12. Costa LB, Perez LG, Palmeira VA, Cordeiro TM, Ribeiro VT, Lanza K, Simoes e Silva AC. Insights on SARS-CoV-2 molecular interactions with the renin–angiotensin system. Front Cell Dev Biol. 2020;8:951. doi:10.3389/fcell.2020.00551.
    13. Valadao PAC, Santos KBS, Ferreira e Vieira TH, Cordeiro TM, Teixeira AL, Guatimosim C, Miranda AS. Inflammation in Huntington's disease: a few new twists on an old tale. J Neuroimmunol. 2020;348:577380. doi:10.1016/j.jneuroim.2020.577380.
    14. Araujo SA, Cordeiro TM, Belisario AR, Araujo RFA, Marinho PES, Kroon EG, Oliveira DB, Teixeira MM, Silva ACS. First report of collapsing variant of focal segmental glomerulosclerosis triggered by arbovirus: dengue and Zika virus infection. Clin Kidney J. 2019;12:355-361. doi:10.1093/ckj/sfy100.
    15. Machado CA, Silva ACS, de Miranda AS, Cordeiro TM, Ferreira RN, de Souza LC, Teixeira AL. Immune-based therapies for traumatic brain injury: insights from pre-clinical studies. Curr Med Chem. 2019;26:Epub ahead of print. doi:10.2174/0929867326666190719123028.
    16. Guimaraes FTL, Brito-Melo GE, Cordeiro TM, Feracin V, Rochavieira E, Pinheiro SVB, Miranda AS, Silva ACS. T-lymphocyte expressing inflammatory cytokines underlie persistence of proteinuria in children with idiopathic nephrotic syndrome. J Pediatr (Rio J). 2018;94:546-553. doi:10.1016/j.jped.2017.09.005.
    17. Filha RS, Pinheiro SVB, Cordeiro TM, Feracin V, Vieira ELM, Miranda AS, Simoes e Silva AC. Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome. Biosci Rep. 2018;39:BSR20181361. doi:10.1042/BSR20181361.
    18. Baracho NCV, Silveira KD, Rocha NP, Cordeiro TM, Feracin V, Pereira RM, Reis MAA, Teixeira MM, Silva ACSE. Urinary cytokine profiles according to the site of blockade of the renin–angiotensin system in nephrectomized rats. J Bras Nefrol. 2017;39:108-118. doi:10.5935/0101-2800.20170020.
    19. Miranda AS, Cordeiro TM, Soares TMSL, Ferreira RN, Simoes e Silva AC. Kidney–brain axis inflammatory cross-talk: from bench to bedside. Clin Sci. 2017;131:1093-1105. doi:10.1042/CS20170050.